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SR1903 TFA

SKU: orb1739809

Description

SR-1903 is a dual modulator acting as an inverse agonist of RORγ and an agonist of LXR, with additional binding to PPARγ without activation. It suppresses LPS-induced inflammatory pathways, including TREM-1, IL-6, and IL-33, while promoting lipid metabolism genes like ABCG1. This compound has demonstrated efficacy in preclinical models of autoimmune arthritis and metabolic disorders, reducing inflammation, cholesterol, and body weight.

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Key Properties

CAS Number2351884-03-0
MW637.54
FormulaC29H28F9N3O3
SMILESC(C(O)=O)(F)(F)F.CC1=C(C2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)C=CC(CN3CCN(CC=4C=CN=CC4)CC3)=C1
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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SR1903 TFA (orb1739809)

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