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SRI-011381 hydrochloride

SKU: orb1218490

Description

SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.

Images & Validation

Key Properties

CAS Number2070014-88-7
MW365.94
Purity>98% (HPLC)
FormulaC20H32ClN3O
SMILESCl.O=C(NC1CCCCC1)N(CC1CCNCC1)Cc1ccccc1
TargetTGFBR
SolubilityDMSO: 10 mM

Bioactivity

In Vivo
SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice. Animal model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE). Dosage: 30 mg/kg. Administration: Intraperitoneally injection; every 2 d; for 22 days. Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
In Vitro
SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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SRI-011381 hydrochloride (orb1218490)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
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% Tween 80 +
%

Available Sizes

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2 mg
$ 80.00
5 mg
$ 110.00
10 mg
$ 180.00
25 mg
$ 340.00
50 mg
$ 540.00
100 mg
$ 780.00
500 mg
$ 1,660.00