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ST-899

SKU: orb3135436

Description

ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS). The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.

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Key Properties

CAS Number143484-41-7
MW518.83
FormulaC22H29BrClNO6
SMILESC(\COC(C[C@@H](OC(CC(C)C)=O)C[N+](C)(C)C)=O)=C\1/C=2C(C(=O)O1)=CC=C(Cl)C2.[Br-]
TargetTNF,PAFR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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ST-899 (orb3135436)

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