STAT3 Rabbit mAb [KD Validated] Antibody

SKU: orb1951799

Description

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.

Images & Validation

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Item 1 of 4

Tested Applications	ICC, IHC, WB
Dilution range	WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
Reactivity	Human, Mouse, Rat

Key Properties

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Antibody Type	Recombinant Antibody
Host	Rabbit
Clonality	Monoclonal
Isotype	Rabbit IgG
Immunogen	A synthesized peptide derived from human STAT3
Purification	Affinity-chromatography
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Form/Appearance	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer	For research use only

Alternative Names

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APRF;Acute-phase response factor;Signal transducer and activator of transcription 3; STAT3; HIES;

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STAT3 Rabbit mAb [KD Validated] Antibody

All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.

Immunofluorescent analysis of Hela cells treated with IFNalpha, using STAT3 Antibody.

Immunohistochemical analysis of paraffin-embedded rat brain, using STAT3 Antibody.

Western blot analysis of STAT3 expression in (1) A431 cell lysate; (2) Human liver lysate; (3) Mouse heart lysate; (4) Rat brain lysate.

Quick Database Links

UniProt

P40763

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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IHC

Immunohistochemistry

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ICC

Immunocytochemistry

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