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STING agonist-12

SKU: orb1297845

Description

Compound 53, an oxindole-based STING agonist, potently activates human STING with an EC50 of 185 nM in both primary and immortalized cells, eliciting a characteristic cytokine profile. This small molecule is a valuable tool for probing STING pathway immunobiology in vitro and has been utilized in preclinical in vivo studies for cancer immunotherapy research.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2259624-71-8
MW490.88
Purity98.29% (May vary between batches)
FormulaC25H19ClF4N2O2
SMILESCC1(C)C(=O)N(Cc2c(F)cccc2Cl)c2cc(ccc12)C(=O)NCc1c(F)cc(F)cc1F
TargetSTING
SolubilityDMSO:60 mg/mL (122.23 mM)

Bioactivity

Target IC50
STING:185 nM (EC50)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, MPYS, inhibit, MITA, ERIS, HEK293T, TMEM173, Stimulator of Interferon Genes, STING, STING activator Compound 53, STING agonist 12, STING agonist12, STING agonist-12
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Key Properties

No computed properties available.

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Protocol Information

STING agonist-12 (orb1297845)

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Available Sizes

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1 mg
$ 80.00
5 mg
$ 120.00
1 ml x 10 mM (in DMSO)
$ 130.00
10 mg
$ 170.00
25 mg
$ 310.00
50 mg
$ 470.00
100 mg
$ 670.00
200 mg
$ 940.00
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