STING Agonist D61

SKU: orb1980021

Description

STING agonist D61 is a compound that activates the stimulator of interferon genes (STING), leading to the induction of IFN3-inducible secreted alkaline phosphatase (SEAP) and IFN-β-inducible reporter genes in cellular assays, with half-maximal effective concentrations (EC50s) of 52.9 and 116 nM, respectively. At concentrations of 4, 6, and 8 µM, D61 enhances the production of IFN-β and chemokine (C-X-C motif) ligand 10 (CXCL10) mRNA, as well as the phosphorylation of TANK-binding kinase 1 (TBK1), IRF3, and STING in THP-1 monocytes. Additionally, when administered at a dose of 0.25 mg/kg every other day, D61 effectively reduces tumor volume in a CT26 murine colon cancer model without impacting the body weight of the subjects.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	2850251-27-1
MW	610.60
Formula	C₂₉H₂₉F₃N₈O₄
SMILES	COC1=C2C(N=C(NC(C3=CC(C)=NN3CC)=O)N2CCCNC4=NC=C(C5=C(C(F)(F)F)C=CC=C5)O4)=CC(C(N)=O)=C1
Target	STING,Others

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

STING,Others

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