Stylopine hydrochloride

SKU: orb1301473

Description

Stylopine is a protoberberine alkaloid investigated for its potential anti-inflammatory properties. Research applications include in vitro studies on inflammatory pathways and in vivo models exploring its therapeutic effects, positioning it as a compound of interest for pharmacological research.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Neuroscience

Images & Validation

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Key Properties

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CAS Number	96087-21-7
MW	359.8
Purity	99.34% (May vary between batches)
Formula	C₁₉H₁₈ClNO₄
SMILES	Cl.C1Oc2cc3CCN4Cc5c6OCOc6ccc5CC4c3cc2O1
Target	Parasite,NOS,COX
Solubility	DMSO:3.6 mg/mL (10.01 mM)

Bioactivity

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In Vitro

Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries. Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner. Suggest that stylopine suppress the NO and PGE2 production in macrophages by inhibiting the iNOS and COX-2 expressions. These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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COX-2, Corydalis, (±)-Stylopine, alkaloid, anti-parasitic, Inhibitor, Inos, inhibit, Tetrahydrocoptisine, Stylopine hydrochloride, Stylopine Hydrochloride

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Compound Identifiers

PubChem CID

131864060 ↗

Key Properties

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No computed properties available.

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