Sultopride hydrochloride

SKU: orb1220509

Description

Sultopride Hydrochloride is a selective dopamine D2 and D3 receptor antagonist.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	23694-17-9
MW	390.93
Purity	>98% (HPLC)
Formula	C₁₇H₂₇ClN₂O₄S
SMILES	Cl.CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)CC
Target	Dopamine Receptor
Solubility	DMSO:50 mg/mL (127.90 mM)

Bioactivity

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In Vivo

Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor. DOPAC and HVA levels in the striatum, the nucleus accumbens and the medial prefrontal cortex are higher in the rats treated with Sultopride hydrochloride and sulpiride than those of the controls. In the striatum, DOPAC and HVA levels are higher in the Sultopride hydrochloride-treated rats than the sulpiride-treated rats (p<0.05). In the nucleus accumbens, DOPAC levels are higher in the Sultopride hydrochloride-treated rats than sulpiride treated rats (p<0.05). In the Sultopride hydrochloride-treated rats, DOPAC and HVA levels are higher in the striatum or in the nucleus accumbens than in the medial prefrontal cortex (p<0.05).

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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LIN-1418 hydrochloride

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Gene Symbol

Dopamine Receptor

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