Suramin sodium salt

SKU: orb1226602

Description

Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity; inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34; induces accumulation of CRL substrates; also inhibits multiple viruses (ZIKVs, EV71).Parasite Infection Approved.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	129-46-4
MW	1429.171
Purity	>98% (HPLC)
Formula	C₅₁H₃₄N₆Na₆O₂₃S₆
SMILES	O=C(C1=CC=C(C)C(NC(C2=CC(NC(NC3=CC(C(NC4=C(C)C=CC(C(NC5=C(C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C6)C6=C(S(=O)([O-])=O)C=C5)=O)=C4)=O)=CC=C3)=O)=CC=C2)=O)=C1)NC7=CC=C(S(=O)([O-])=O)C8=C7C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C8.[Na+].[Na+].[Na+].[Na+].[Na+].
Target	E3 Ubiquitin Ligase
Solubility	H2O: ≥ 200 mg/mL; DMSO: 5.6 mg/mL (Need warming)

Bioactivity

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In Vivo

Animal model: Adult male Wistar rats (200-225 g). Dosage: 10 mg/kg. Administration: IV; twice weekly for 3 weeks. Result: Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure.

In Vitro

Cell Proliferation Assay Cell line: HO-8910 PM ovarian and Hela cervical cancer cells. Concentration: 50, 100, 200, 300, 400, 500 and 600 μg/mL. Incubation time: For 24, 48, 72 and 96 hours. Result: Inhibited cells proliferation in a dose-dependent and time-dependent manner. Apoptosis Analysis Cell line: HeLa cells. Concentration: 300 μg/mL. Incubation time: For 48 hours. Result: Induced cells apoptosis. Western blot analysis. Cell line: PA-SMCs cells. Concentration: 1 mg/mL. Incubation time: For 1 hour. Result: Significantly suppressed the phosphorylated ERK1/2.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Suramin hexasodium salt | BAY-205 | NF-060

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Gene Symbol

E3 Ubiquitin Ligase

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