Tallimustine HCl

SKU: orb1819143

Description

Tallimustine HCl is a DNA inhibitor, an AT-specific alkylated antitumor derivative of diamycin.Tallimustine HCl can be used in severe combined immunodeficiency mouse models of adult myelogenous leukemia, which can be used for the treatment of leukemia.

Research Area

Molecular Biology

Images & Validation

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Key Properties

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CAS Number	118438-45-2
MW	734.08
Purity	99.62%
Formula	C₃₂H₃₉Cl₃N₁₀O₄
SMILES	Cl.O=C(NC=1C=C(C(=O)NC=2C=C(C(=O)NC=3C=C(C(=O)NCCC(=N)N)N(C3)C)N(C2)C)N(C1)C)C4=CC=C(C=C4)N(CCCl)CCCl
Target	Others,DNA
Solubility	DMSO:45 mg/mL (61.3 mM)

Bioactivity

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Target IC50	CEM cells:3.5 nM
In Vivo	Tallimustine HCl (3 mg/kg; i.p.; ) prolonged survival and shows antileukemic activity in L1210 tumor-bearing mice and
In Vitro	Tallimustine HCl (0.1-10 μM; 4 h) causes harm to isolated SV40 DNA. Additionally, Tallimustine HCl exhibits cytotoxicity in CEM cells after 72 hours, displaying an IC50 of 3.5 nM Tallimustine HCl (25 and 100 nM, 6 dayss) induces erythroid differentiation of K562 cells Tallimustine HCl (100 nM, 6 dayss) increases accumulation of γ-globin mRNA in K562 cells Tallimustine HCl (0.5 μg/ml, 1 h) arrests SW626 cells in G2/M phase Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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DNA, Tallimustine HCl, Tallimustine HCl(115308-98-0 Free base)

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Compound Identifiers

PubChem CID

6918104 ↗

Key Properties

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No computed properties available.

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