Talquetamab Antibody

SKU: orb1980562

Description

Talquetamab is a bispecific antibody targeting GPRC5D and CD3, designed for the treatment of multiple myeloma. It redirects T-cells to eliminate GPRC5D-expressing myeloma cells, demonstrating cytotoxic activity in both in vitro assays and in vivo preclinical models.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2226212-40-2
MW	144.59 kDa
Purity	99.7% (SEC-HPLC)
Target	Integrin,Dopamine Receptor

Bioactivity

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In Vivo	Talquetamab (JNJ-64407564), administered subcutaneously or intravenously at doses ranging from 0.1 to 50 µg, exhibits significant anti-tumor activity in H929 and MM mouse models . Read more...
In Vitro	Talquetamab, at concentrations ranging from 0.00128 to 4.0 μg/mL for 48 hours, effectively induces lysis of multiple myeloma cells. This induction is accompanied by a significant dose-dependent increase in the proportion of activated CD4+ and CD8+ T cells, as well as elevated levels of granule enzyme B and inflammatory cytokines such as IL-6, IL-8, and TNF-α . Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DopamineReceptor, Dopamine Receptor, D3, JNJ-7564, JNJ-64407564

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Gene Symbol

Integrin,Dopamine Receptor

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