Talquetamab Antibody

SKU: orb1980562

Description

Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2226212-40-2
MW	144.59 kDa
Purity	99.7% (SEC-HPLC)
Target	Dopamine Receptor,Integrin

Bioactivity

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In Vivo	Talquetamab (JNJ-64407564), administered Subcutaneously or intravenously at doses ranging from 0.1 to 50 µg, exhibits significant anti-tumor activity in H929 and mM mouse models. Read more...
In Vitro	Talquetamab, at concentration ranging from 0.00128 to 4.0 μg mL for 48 hours, effectively induces lysis of multiple myeloma cells. This induction is accompanied by a significant dose-dependent increase in the proportion of activated CD4+ and CD8+ T cells, as well as elevated levels of granule enzyme B and inflammatory cytokines such as IL-6, IL-8, and TNF-α. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Disclaimer	For research use only

Alternative Names

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DopamineReceptor, Dopamine Receptor, D3, JNJ-7564, JNJ-64407564

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Gene Symbol

Dopamine Receptor,Integrin

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