Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils: ATTO 488

SKU: orb3012995

Description

Human Recombinant Tau-441 (2N4R) P301S Mutant PFFs: ATTO 488

Images & Validation

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Tested Applications	In vitro, In vivo, SDS-PAGE, WB
Application Notes	Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs:ATTO-488 are combined with active tau monomers. Passed sterility test (OD600 equivlaent to negative control (dH20) after 139 hr incubation at 37C, 200 rpm in rich medium)

Key Properties

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Source	Recombinant
Expression System	E. coli
Biological Origin	Human
Target	Tau-441 (2N4R) P301S PFFs
Tag	ATTO 488
Protein Length	Full Length
Protein Sequence	MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVSGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
Purification	Ion-exchange Purified
Purity	>95%

Storage & Handling

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Storage	-80°C
Buffer/Preservatives	PBS pH 7.4, 0.09% Azide
Concentration	Lot/batch specific. See included datasheet.
Dry Ice Shipping	Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
Disclaimer	For research use only

Alternative Names

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Tau PFFs, Tau PFF, Tau protein Pre-formed Fibrils, Tau aggregates, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, mouse Tau protein, P301S mutant Tau, 2N4R Tau, Tau441, fluorescent Tau fibrils, ATTO 488 conjugated Tau, ATTO labelled Tau fibrils

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Quick Database Links

Gene Symbol

Tau-441 (2N4R) P301S PFFs

UniProt

P10636

UniProt Details

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No UniProt data available

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Datasheet

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Protocol Information

Western Blot (IB, immunoblot)

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SDS-PAGE

Sodium Dodecyl Sulphate PolyAcrylamide Gel Electrophoresis

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