Taurochenodeoxycholic Acid

SKU: orb1304752

Description

Taurochenodeoxycholic acid, also known as 12-deoxycholyltaurine, is a primary taurine-conjugated bile acid found in animal bile. It is utilized in research to investigate bile acid metabolism, hepatoprotective mechanisms, and gastrointestinal physiology in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	516-35-8
MW	499.7
Purity	99.86% (May vary between batches)
Formula	C₂₆H₄₅NO₆S
SMILES	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@H]3O)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(NCCS(=O)(=O)O)=O)C)[H])[H]
Target	Apoptosis,Endogenous Metabolite,Caspase,TNF
Solubility	DMSO:50 mg/mL (100.06 mM);H2O:100 mg/mL (200.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4 mM)

Bioactivity

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In Vivo

Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation. Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats.Taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg can decrease the pulmonary coefficient in the model mice, taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg reduce the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice, the expression level of MMP-9 increases, while it has no significant effects on MMP2.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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acid, 12-Deoxycholyltaurine, bile, Apoptosis, anti-inflammatory, Chenyltaurine, Chenodeoxycholyltaurine, Caspase, caspase-3, caspase-8, inhibit, JNK, mRNA, immune, NR8383, Inhibitor, EndogenousMetabolite, Endogenous Metabolite, Taurochenodeoxycholate, Taurochenodeoxycholic Acid, TCDCA, regulation, TNF-α, TIMP-2, PKC

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Compound Identifiers

PubChem CID

387316 ↗

Key Properties

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No computed properties available.

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