TC 14012 hydrochloride

SKU: orb1980034

Description

TC 14012, a peptidomimetic compound, acts as both an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4; IC50 = 2.9 nM) and as an agonist for CXCR7, effectively recruiting β-arrestin in HEK293T cells that express CXCR7 (EC50 = 350 nM). Moreover, it demonstrates significant antiviral activity by reducing the cytopathic effects of HIV in MT-4 cells with an EC50 value of 0.4 nM and inhibiting HIV entry in vitro through a CXCR4-dependent pathway (IC50 = 19.3 nM). Additionally, TC 14012 suppresses chemokine (C-X-C motif) ligand 12 (CXCL12)-induced migration in MDA-MB-231 breast cancer and human umbilical vein endothelial cells (HUVECs) within the 10 to 1,000 nM concentration range. In a mouse model, administration of TC 14012 at 10 mg/kg significantly reduced infarct size following acute myocardial infarction induced by ligation of the left anterior descending (LAD) coronary artery.

Images & Validation

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Key Properties

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MW	2066.42
Formula	C₉₀H₁₄₀N₃₄O₁₉S₂.XHCl
SMILES	O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@](CSSC[C@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)CC1=CC(C=CC=C2)=C2C=C1)=O)C3=O)([H])C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=O)=O)([H])CCCNC(N)=N)=O)CC4=CC=C(O)C=C4)[C@@](CCC5)([H])N5C([C@@](NC([C@@H](NC([C@](NC([C@@H](N3)CC6=CC=C(O)C=C6)=O)([H])CCCNC(N)=O)=O)CCCCN)=O)([H])CCCNC(N)=O)=O.Cl

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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