Teclistamab Antibody

SKU: orb1980563

Description

Teclistamab (JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor expressed on the surface of t-cells and the b-cell maturation antigen (BCMA) expressed on the surface of malignant multiple myeloma b-lineage cells for the treatment of relapsed and refractory multiple myeloma.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2119595-80-9
Purity	95.00%
Target	Integrin

Bioactivity

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In Vitro	Methods: Frozen BM MNCs were treated with Teclistamab (0-532 nM) with or without exogenous healthy T cells to measure target engagement and killing. Results: Teclistamab-induced cytotoxicity in BM MNCs had comparable EC50s (1.5-4.2 nM) in All 3 patient Samples; Teclistamab-mediated T cell activation was also similar in All BM MNC Samples with EC50s (0.93 - 1.75 nM). Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Disclaimer	For research use only

Alternative Names

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JNJ64007957, JNJ-64007957

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Quick Database Links

Gene Symbol

Integrin

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