Teclistamab Antibody

SKU: orb1980563

Description

Teclistamab is a bispecific antibody engaging CD3 on T-cells and BCMA on myeloma cells, designed for relapsed/refractory multiple myeloma research. It is utilized in preclinical in vitro cytotoxicity assays and in vivo xenograft models to study T-cell redirection and antitumor efficacy.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2119595-80-9
MW	143.64 kDa
Purity	95.00%
Target	Integrin

Bioactivity

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In Vitro	Methods: Frozen BM MNCs were treated with Teclistamab (0-532 nM) with or without exogenous healthy T cells to measure target engagement and killing. Results: Teclistamab-induced cytotoxicity in BM MNCs had comparable EC50s (1.5-4.2 nM) in all 3 patient samples; Teclistamab-mediated T cell activation was also similar in all BM MNC samples with EC50s (0.93 - 1.75 nM). Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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JNJ64007957, JNJ-64007957

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Quick Database Links

Gene Symbol

Integrin

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