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Telratolimod

SKU: orb1940690

Description

Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.(In Vivo):Telratolimod (50 μg) suppresses the tumor volume and more effectively blocks tumor growth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs the survival of mice bearing large tumors .

Images & Validation

Key Properties

CAS Number1359993-59-1
MW593.901
Purity>98% (HPLC)
FormulaC36H59N5O2
SMILESCCCCCCCCCCCCCCCCCC(=O)NCCCCOn1c(CCCC)nc2c(N)nc3ccccc3c12
TargetTLR
SolubilityIn Vitro: DMSO : 62.5 mg/mL (105.24 mM)

Bioactivity

In Vivo
Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors.
In Vitro
Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MEDI9197 | 3M-052

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    1359993-59-1

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    C36H59N5O2

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 2 mg
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Protocol Information

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