Tesidolumab Antibody

SKU: orb1980612

Description

Tesidolumab (LFG316) is a fully human anti-C5 monoclonal antibody that inhibits C5 cleavage, preventing membrane attack complex formation. It is a research tool for studying complement-mediated pathologies, including extravascular hemolysis, in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	1531594-08-7
MW	142 kDa (average)
Purity	99.72% (SEC-HPLC)
Target	Complement System

Bioactivity

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In Vitro	Tesidolumab (LFG316) has a half-life of approximately 9 days in humans and binds to a unique epitope distant from Arg 885, differentiating it from eculizumab and ravulizumab in its binding site. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Tesidolumab, LFG 316, LFG316, LFG-316, ComplementSystem, complement 5a receptor (C5aR), Complement System

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Gene Symbol

Complement System

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