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Tetrandrine

SKU: orb1304758

Description

Tetrandrine is a natural bisbenzylisoquinoline alkaloid that acts as a calcium channel blocker, inhibiting both voltage-gated calcium channels and Ca2+-activated potassium channels. It is widely used in pharmacological research, including in vitro ion channel studies and in vivo models for investigating cardiovascular and anti-inflammatory pathways.

Research Area

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number518-34-3
MW622.75
Purity99.94% (May vary between batches)
FormulaC38H42N2O6
SMILESO(C)C1=C2C=3[C@](CC=4C=C(C(OC)=CC4)OC=5C=CC(C[C@]6(C7=CC(O2)=C(OC)C=C7CCN6C)[H])=CC5)(N(C)CCC3C=C1OC)[H]
TargetPotassium Channel,Calcium Channel,Parasite
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:0.7 mg/mL (1.12 mM);DMSO:12.45 mg/mL (19.99 mM)

Bioactivity

In Vivo
METHODS: To detect anti-tumor activity in vivo, athymic nude mice bearing THP-1 xenografts were administered Tetrandrine (25-50 mg/kg, 0.5% methylcellulose) by gavage once daily for 13 days. RESULTS: Tetrandrine treatment reduced tumor growth.
In Vitro
METHODS: Leukemia cell lines K562, THP-1, U937, and HL60 were treated with Tetrandrine (1-3 µM) for 24-72 h, and cell numbers were measured. RESULTS: 2 µM and 3 µM Tetrandrine significantly inhibited cell proliferation. METHODS: A panel of GFP-LC3-expressing tumor cell lines MCF-7, PLC-5, SK-Hep1, HeLa, and PC3 cells were treated with Tetrandrine (5 µM) for 16 h and GFP-LC3 spots were detected. RESULTS: Tetrandrine significantly induced GFP-LC3 spot formation with similar potency (5 µM) in all cell lines tested.Tetrandrine induced autophagy in multiple cell lines.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Ca2+ channels, Calcium Channel, Ca channels, d-Tetrandrine, CalciumChannel, Inhibitor, Fanchinine, Hanfangchin A, KcsA, inhibit, NSC 77037, NSC77037, NSC-77037, Tetrandrine, Potassium Channel, PotassiumChannel, Sinomenine A

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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100 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 90.00
500 mg
$ 130.00
DispatchUsually dispatched within 5-10 working days
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