TFAM activator 1

TFAM activator 1 (Compound 2) is a mitochondrial transcription factor A (TFAM) activator with anti-inflammatory properties and the ability to repair mitochondrial dysfunction. It enhances TFAM protein levels and mitochondrial DNA copy number, inhibits mitochondrial DNA-induced inflammatory responses by preventing mitochondrial DNA from escaping into the cytosol, thereby reducing cytokine production (TNF-α, CXCL-10, and IFN). Additionally, it significantly raises ATP levels, decreases fibrosis markers, and strengthens Treg 240 function. TFAM activator 1 is useful for investigating mitochondrial dysfunctions, such as those in Parkinson's and Alzheimer's disease.