Cart summary

You have no items in your shopping cart.

TG6-10-1

SKU: orb1223317

Description

TG6-10-1 is a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2. Systemic administration of TG6-10-1 completely recapitulates the effects of conditional ablation of cyclooxygenase-2 from principal forebrain neurons, namely reduced delayed mortality, accelerated recovery from weight loss, reduced brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely. TG6-10-1 shows low-nanomolar antagonist activity against EP2.

Images & Validation

Key Properties

CAS Number1415716-58-3
MW448.43
Purity>98% (HPLC)
FormulaC23H23F3N2O4
SMILESC(=O)(/C=C/c1cc(c(c(c1)OC)OC)OC)NCCn1c(cc2ccccc12)C(F)(F)F
TargetPI3K
SolubilityDMSO : ≥ 100 mg/mL; 223.00 mM

Bioactivity

In Vivo
TG6-10-1 (5 mg/kg; i.p.; 4-30 hours) improves survival, accelerates recovery of lost weight, and improves functional recovery following status epilepticus (SE). Animal model: C57BL/6 mice (pilocarpine-induced SE). Dosage: 5 mg/kg. Administration: Intraperitoneal injection; 4, 21, 30 hours. Result: A significant increase in survival and accelerating the recovery of lost weight in post-SE mice.
In Vitro
TG6-10-1 robustly blocks prostaglandin E2 (PGE2) (10 μM)-induced cAMP accumulation in a concentration-dependent manner in SH-SY5Y cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TG6-10-1 | TG 6-10-1 | TG-6-10-1 | TP6101

Similar Products

  • TG6-10-1 [orb1305497]

    99.66%

    1415716-58-3

    448.43

    C23H23F3N2O4

    25 mg, 50 mg, 1 ml x 10 mM (in DMSO), 5 mg, 10 mg, 1 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

TG6-10-1 (orb1223317)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

200 mg
500 mg
2 mg
$ 120.00
5 mg
$ 180.00
10 mg
$ 230.00
25 mg
$ 370.00
50 mg
$ 540.00
100 mg
$ 800.00