Cart summary

You have no items in your shopping cart.

TH1760

SKU: orb2900618

Description

TH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine.

Images & Validation

Key Properties

CAS Number2567914-01-4
MW426.45
Purity>98% (HPLC)
FormulaC20H18N4O5S
SMILESS(=O)(=O)(C=1C=C2C(=CC1)NC(=O)O2)N3CCN(C(=O)C=4C=C5C(=CC4)NC=C5)CC3

Bioactivity

In Vitro
Western blot analysis. Cell line: HCT116 cells. Concentration: 10 μM. Incubation time: 4 h. Result: Inhibited the expression of NUDT15. Western blot analysis. Cell line: AML HL-60 cells. Concentration: 10 μM. Incubation time: 3 h. Result: Significantly inhibited the expression of NUDT15 when the temperature was higher than 54°C.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • TH1760 [orb1685551]

    97.03%

    2567914-01-4

    426.45

    C20H18N4O5S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

TH1760 (orb2900618)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

500 mg
5 mg
$ 90.00
10 mg
$ 140.00
25 mg
$ 270.00
50 mg
$ 480.00
100 mg
$ 680.00