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Thailanstatin A

SKU: orb1303603

Description

Thailanstatin A is an ultra-potent eukaryotic RNA splicing inhibitor that non-covalently targets the SF3b subunit, exhibiting low-nanomolar cytotoxicity against various cancer cell lines. It serves as a potent payload for antibody-drug conjugates (ADCs), such as when conjugated to trastuzumab, and is used in cancer research for both in vitro and in vivo studies of spliceosome inhibition.

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Key Properties

CAS Number1426953-21-0
MW535.63
Purity93.69% (May vary between batches)
FormulaC28H41NO9
SMILESC[C@H](OC(C)=O)\C=C/C(=O)N[C@@H]1C[C@H](C)[C@H](C\C=C(/C)\C=C\[C@H]2O[C@H](CC(O)=O)C[C@@]3(CO3)[C@@H]2O)O[C@@H]1C
TargetADC Cytotoxin
SolubilityDMSO:245 mg/mL (457.41 mM)

Bioactivity

In Vitro
Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 . Thailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) shows potent antiproliferative activities with GI 50 s in the single nM range (1.11-2.69 nM) .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

antiproliferative, ADC, ADCCytotoxin, ADC Cytotoxin, ADC Payload, inhibit, Inhibitor, linker, natural, RNA, spliceosome, subunit, SF3b, Thailanstatin A

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Key Properties

No computed properties available.

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Thailanstatin A (orb1303603)

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1 mg
$ 230.00
5 mg
$ 590.00
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