Thapsigargin

SKU: orb1296066

Description

Thapsigargin

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	67526-95-8
MW	650.75
Purity	99.22%
Formula	C₃₄H₅₀O₁₂
SMILES	CCCCCCCC(=O)O[C@@H]1[C@@H](OC(=O)C(C)=CC)C(C)=C2[C@@H]3OC(=O)[C@@](C)(O)[C@@]3(O)[C@H](C[C@](C)(OC(C)=O)[C@@H]12)OC(=O)CCC
Target	Apoptosis,Calcium Channel,SARS-CoV
Solubility	DMSO:252.5 mg/mL (388.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.68 mM)

Bioactivity

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Target IC50	PC3 cells:2.4 μM\|CCRF S-180 cells:30 nM\|K562 cells:0.17 μM\|CCRF-CEM cells:0.27 μM\|MCF-7 cells:2.3 μM\|EL4 cells:0.1 μM\|HL-60 cells:0.007 μM
In Vivo	METHODS: To assay in vivo ER stress-inducing activity, Thapsigargin (0.25-1 μg/g in 150 mM dextrose containing 1% DMSO) was administered as a single intraperitoneal injection to Balb/c mice in order. RESULTS: Thapsigargin treatment resulted in significant expression of the ER stress markers ATF6 and eIF2α in adipose tissue. thapsigargin treatment failed to induce the expression of most of the ER stress and UPR proteins in the liver. METHODS: To investigate the antiviral function in vivo, Thapsigargin (30 ng/mouse) was administered by gavage to PR8 virus-infected BALB/c mice once daily for seven days. RESULTS: Oral administration of Thapsigargin to mice significantly reduced severity and viral shedding and improved survival during infection with the deadly influenza virus. Read more...
In Vitro	METHODS: Human rheumatoid arthritis synoviocytes MH7A were treated with Thapsigargin (0.001-1 μM) for 2-4 days, and cell proliferation was detected using the SRB. RESULTS: Thapsigargin inhibited the proliferation of MH7A cells in a time- and dose-dependent manner. METHODS: Human hepatocellular carcinoma cells HepG2 were treated with Thapsigargin (25-100 nM) for 24 h. Endoplasmic reticulum stress/UPR gene expression was detected by RT-qPCR. RESULTS: Thapsigargin treatment consistently induced ER stress gene expression only at elevated concentrations of 50 and 100 nM. Read more...
Cell Research	Cell Line: MH7A human rheumatoid arthritis synovial cells. Concentration: 0.001, 0.1, and 1 μM. Incubation Time: For 2 and 4 days
Animal Research	Animal Model: Male Balb/c mice (20-25g). Dosage: 0.25ug/g, 0.5ug/g and 1ug/g. Administration: Injection; 24 hours

Storage & Handling

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Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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unfolded, protein ,response, SARSCoV, SARS coronavirus, SARS-CoV, stress, Thapsigargin, inhibit, Inhibitor, Apoptosis, CalciumChannel, Ca2+ channels, Ca2+-ATPase, Calcium Channel, Ca channels, coronavirus

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Compound Identifiers

PubChem CID

49926 ↗

Key Properties

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No computed properties available.

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Thapsigargin (orb1296066)

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CAS Number:	216571-99-2
MW:	876.36
Formula:	C₄₄H₅₇B₃F₂N₂O₁₂₂-

Purity:	>98% (HPLC)
CAS Number:	245747-08-4
MW:	418.3
Formula:	C₁₇H₉F₇N₄O

Purity:	>98% (HPLC)
CAS Number:	67526-95-8
MW:	650.8
Formula:	C₃₄H₅₀O₁₂

Thapsigargin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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