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ThioLox

SKU: orb1745219

Description

ThioLox is a potent and competitive 15-LOX-1 inhibitor (IC50 = 12 µM) with demonstrated neuroprotective and anti-inflammatory properties. It has shown protective effects against glutamate-induced toxicity in cellular models, supporting its research utility in studying oxidative stress and neuroinflammation pathways.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1202193-89-2
MW274.38
Purity>99.99% (May vary between batches)
FormulaC15H18N2OS
SMILESC(NCCCC)(=O)C=1C=C(SC1N)C2=CC=CC=C2
TargetLipoxygenase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.03 mM);DMSO:90 mg/mL (328.01 mM)

Bioactivity

Target IC50
15-LOX1:3.3 (Ki)
In Vivo
The logP value of ThioLox is 3, indicating that it is predicted to effectively penetrate the blood-brain barrier.
In Vitro
ThioLox (50 μM; 24 h) inhibits the expression of interleukins (IL-1β, IL-6, IL-8, IL-12b, TNFα, and iNOS) in precision-cut lung slices (PCLS). In neuronal cells, ThioLox (10 μM; 16 h) prevents mitochondrial superoxide formation and lipid peroxidation. ThioLox (5-20 μM; 14-16 h) prevents HT-22 cells from glutamate toxicity. ThioLox significantly reduces neuronal cell death.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

15 LOX, ThioLox
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

ThioLox (orb1745219)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 80.00
10 mg
$ 90.00
25 mg
$ 150.00
50 mg
$ 220.00
100 mg
$ 360.00
200 mg
$ 490.00
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