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Tipranavir

SKU: orb1745235

Description

Tipranavir is a protease inhibitor effective against multi-PI-resistant HIV-1, inhibiting both viral protease activity and dimerization. It also demonstrates inhibitory activity against SARS-CoV-2 3CLpro, making it a useful research tool for studying antiviral mechanisms in vitro.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number174484-41-4
MW602.66
Purity99.85% (May vary between batches)
FormulaC31H33F3N2O5S
SMILESCCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(cn3)C(F)(F)F)c2)C(=O)O1
TargetSARS-CoV,HIV Protease
SolubilityDMSO:260 mg/mL (431.42 mM);Ethanol:45 mg/mL (74.67 mM)

Bioactivity

Target IC50
HIV-1 (isolates):66-410 nM|HIV-1 (isolates):8 pM(Ki )
In Vivo
Tipranavir (5 mg/kg ; mouse model): CLtot was 0.17 ± 0.10 L/h/kg, Vss was 0.51 ± 0.14 L/kg, and t1/2 was 5.4 ±0. 3h. Tipranavir (10 mg/kg ; oral ; rats): got the result of F was 30% compared to 5 mg/kg tipranavir dosing.
In Vitro
Tipranavir (PNU-140690) inhibits HIV-1 protease activity, blocks protease subunit dimerization, and exhibits potent efficacy against a broad range of wild-type and multi-PI-resistant HIV-1 variants.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

HIVProtease, HIV-1 protease, HIV Protease, PNU140690, PNU-140690, PNU 140690, Tipranavir, SARS CoV-1 3CLpro, SARSCoV

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Key Properties

No computed properties available.

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Protocol Information

Tipranavir (orb1745235)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 110.00
5 mg
$ 200.00
1 ml x 10 mM (in DMSO)
$ 260.00
10 mg
$ 330.00
25 mg
$ 690.00
50 mg
$ 1,030.00
100 mg
$ 1,730.00
200 mg
$ 2,270.00
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