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Tirucallol

SKU: orb1297618

Description

Tirucallol is a natural small molecule isolated from Euphorbia lactea with demonstrated topical anti-inflammatory activity in vivo. Its mechanism is associated with the inhibition of neutrophil migration, making it a candidate for research in inflammation and immunology.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number514-46-5
MW426.72
Purity99.98%
FormulaC30H50O
SMILES[H][C@]1(CC[C@]2(C)C3=C(CC[C@@]12C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@]1([H])CC3)[C@@H](C)CCC=C(C)C
TargetNOS,Prostaglandin Receptor,NO Synthase
SolubilityDMSO:4.27 mg/mL (10.01 mM)

Bioactivity

In Vitro
The effect of CMG neutral extract (25-200 microg/ml) and Tirucallol (0.1-100 microM) on the following: 1) the expression of adhesion molecules (VCAM-1 and ICAM-1) by Cell ELISA and 2) the attachment of monocytes (U937 cells) in TNF-alpha stimulated Human Aortic Endothelial Cells (HAEC) by Adhesion assay. The impact of treatment with CMG neutral extract and Tirucallol in NFkB phosphorylation was also examined by a cell-based ELISA kit. Both CMG extract and Tirucallol inhibit significantly VCAM-1 and ICAM-1 expression in TNF-alpha-stimulated HAEC. They also inhibit significantly the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuate the phosphorylation of NFkB p65.

Storage & Handling

Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

antiinflammatory, Euphorbia, Inhibitor, latex, lacteal, NO Synthase, inhibit, NOS, NOSynthase, Prostaglandin Receptor, ProstaglandinReceptor, PGE, Tirucallol, tetracyclic, triterpene

Similar Products

  • Tirucallol [orb1217947]

    >98% (HPLC)

    514-46-5

    426.72

    C30H50O

    1 g, 500 mg, 200 mg, 100 mg, 5 mg, 10 mg, 25 mg, 50 mg
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Key Properties

No computed properties available.

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Tirucallol (orb1297618)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 130.00
5 mg
$ 260.00
10 mg
$ 390.00
25 mg
$ 620.00
50 mg
$ 870.00
100 mg
$ 1,130.00
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