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TKIM

SKU: orb1298701

Description

TKIM

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number326921-25-9
MW371.84
Purity99.47%
FormulaC18H14ClN3O2S
SMILESS(CC(NNC(=O)C1=CC=C(Cl)C=C1)=O)C2=NC3=C(C=C2)C=CC=C3
TargetPotassium Channel
SolubilityDMSO:30 mg/mL (80.68 mM)

Bioactivity

In Vitro
TKIM binds to the pocket o the IM state of TREK-1, which differs fro the binding of common inhibitors, which bind to channels in the inactive state. Overall, identified an allosteric li and-binding site and a new mechanistic inhibitor for TREK-1, suggesting that IM states of ion channels may be promising druggable targets for use in discovering allosteric modulators.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

TREK-1, TKIM, Potassium Channel, PotassiumChannel

Similar Products

  • TKIM [orb1219653]

    >98% (HPLC)

    326921-25-9

    371.1

    C18H14ClN3O2S

    1 g, 500 mg, 200 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
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Key Properties

No computed properties available.

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TKIM (orb1298701)

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Available Sizes

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1 mg
$ 80.00
5 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 180.00
25 mg
$ 280.00
50 mg
$ 380.00
100 mg
$ 490.00
200 mg
$ 640.00
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