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Description

Tkip is a selective JAK2 inhibitor that blocks its autophosphorylation and downstream IFN-γ signaling. This compound is used in research to study immune modulation, antiviral responses, and MHC class I expression in both cellular and animal models of inflammation and autoimmunity.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

TargetMHC,JAK
CAS Number716361-65-8
MW1684.03
FormulaC93H118N16O14
SMILESC([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC)C)=O)C(C)C)=O)=O)=O)[C@H](C)C)=O)CC(C)C)=O)N)C=7C=8C(NC7)=CC=CC8

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
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Tkip (orb2813729)

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