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TLR7 agonist 2

SKU: orb1303015

Description

TLR7 agonist 2 (TLR7-IN-1) is a potent and selective TLR7 agonist with an LEC of 0.4 µM. This small molecule is a valuable research tool for studying TLR7-mediated immune responses in both cellular assays and animal models of antiviral and anticancer immunity.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology

Images & Validation

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TLR7 agonist 2

Key Properties

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CAS Number1642857-69-9
MW336.35
Purity99.33% (May vary between batches)
FormulaC17H16N6O2
SMILESCc1cc(COc2nc(N)nc3ccn(Cc4ccccn4)c23)no1
TargetTLR
SolubilityDMSO:45 mg/mL (133.79 mM)

Bioactivity

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Target IC50
TLR7:LEC: 0.4 μM
Cell Research
The ability of TLR7-agonist-1 to activate human TLR7 and/or TLR8 is assessed by using HEK293 cells. Briefly, HEK293 cells are grown in culture medium (DMEM supplemented with 10% FCS and 2 mM Glutamine). Transfected cells are then detached with Trypsin-EDTA, washed in PBS and resuspended in medium to a density of 1.67×105 cells/mL. Thirty microliters of cells are then dispensed into each well in 384-well plates, where 10 μL of TLR7-agonist-1 in 4% DMSO is already present. Following 6 hours incubation at 37°C, 5% CO2, the luciferase activity is determined by adding 15 μL of Steady Lite Plus substrate to each well and readout performed on a microplate imager. Lowest effective concentrations (LEC) values are determined for TLR7-agonist-1.
Animal Research
In C57Bl/6 mice model,Single oral administration of 0.3, 1, 3, and 10 mg/kg doses of TLR7-agonist-1.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Inhibitor, inhibit, TLR7-IN-1, TLR7-agonist-1, TLR7 agonist 2, TLR-7 agonist 2, TLR7, TLR, Toll-like Receptor (TLR)

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
86346192 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

Select a size below

1 mg
$ 140.00
5 mg
$ 280.00
1 ml x 10 mM (in DMSO)
$ 280.00
10 mg
$ 380.00
25 mg
$ 600.00
50 mg
$ 810.00
100 mg
$ 1,100.00
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