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TLR7/8 agonist 8

SKU: orb1944362

Description

TLR7/8 agonist 8 (compound 24m) is a potent dual agonist for toll-like receptors 7 and 8 (TLR7/8), exhibiting half-maximal effective concentrations (EC50s) of 27 nM for human TLR7 (hTLR7) and 12 nM for human TLR8 (hTLR8). This compound enhances the efficacy of PD-1/PD-L1 inhibitors in antitumor activity.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2649170-16-9
MW418.53
FormulaC24H30N6O
SMILESC(N1CC2(C1)COC2)C3=CC=C(CC4=NC5=C(C=C4)N=C(N)N=C5NCCCC)C=C3
TargetOthers,TLR

Storage & Handling

Storage-20°C
DisclaimerFor research use only

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TLR7/8 agonist 8 (orb1944362)

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