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TLR8 agonist 9

SKU: orb2564597

Description

TLR8 agonist9 (Compound II-77) functions as an agonist for Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. This compound is stable in human and mouse plasma and effectively induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist9 demonstrates significant antitumor activity, achieving a tumor growth inhibition (TGI) rate of 97%.

Images & Validation

Key Properties

CAS Number3034750-61-0
MW725.79
FormulaC38H43N7O8
SMILESO=C1C=CC(=O)N1CC2OCC(C(=O)N3CC4=CC(=CN=C4CC3)NC(=O)C5(C=6C=CC=7C=C(C(=O)N(CCO)CCC)CC(=NC7C6)N)CC5)CO2
TargetTLR

Storage & Handling

Storage-20°C
DisclaimerFor research use only

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TLR8 agonist 9 (orb2564597)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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