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TMC353121

SKU: orb1706528

Description

TMC353121 is a small molecule RSV fusion inhibitor that suppresses viral replication and reduces the production of key pro-inflammatory cytokines and chemokines, including TNF-α, IL-6, and MIP1-α. It is a valuable research tool for studying RSV pathogenesis and antiviral mechanisms in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number857066-90-1
MW558.71
Purity≥98% (May vary between batches)
FormulaC32H42N6O3
SMILESCc1ccc(CCCO)c(NCc2ccc3nc(NCCCN4CCOCC4)n(Cc4nc(C)ccc4O)c3c2)c1
TargetRSV,IL Receptor,TNF
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.58 mM);DMSO:30 mg/mL (53.7 mM)

Bioactivity

Target IC50
RSV:9.9 (pEC50)
In Vivo
After single subcutaneous administration and repeated administration 24 hours post-intranasal RSV inoculation, TMC353121 dose-dependently reduces viral titers in bronchoalveolar lavage fluid.
In Vitro
TMC353121 is an effective RSV fusion inhibitor, active against wild-type RSV (strain LO) with a 50% effective concentration (EC50) of 0.07 ng/mL in HeLaM cells.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

RSV, TNF-α, TMC 353121, TMC353121, TMC-353121, ILReceptor, IL-6, IL Receptor
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

TMC353121 (orb1706528)

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2 mg
$ 190.00
DispatchUsually dispatched within 5-10 working days
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