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δ-Tocotrienol

SKU: orb1297642

Description

Delta-Tocotrienol is a natural vitamin E variant with demonstrated anti-angiogenic and anticancer properties. Research indicates it activates miR-34a, suppressing proliferation, inducing apoptosis, and inhibiting invasion in non-small cell lung cancer cells in vitro, highlighting its potential as a chemopreventive agent.

Research Area

Cardiovascular Research, Cell Biology, Molecular Biology, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

CAS Number25612-59-3
MW396.61
Purity99.86%
FormulaC27H40O2
SMILESCC(C)=CCC\C(C)=C\CC\C(C)=C\CC[C@]1(C)CCc2cc(O)cc(C)c2O1
TargetOthers,Akt,PI3K,p53,PDK,Bcl-2 Family,ERK,VEGFR,NF-κB,Apoptosis,Caspase,DNA/RNA Synthesis
SolubilityDMSO:100 mg/mL (252.14 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (8.32 mM)

Bioactivity

In Vitro
δ-Tocotrienol induced apoptosis and cell cycle arrest at G0/G1 and M phases in nasopharyngeal carcinoma cells. After CNE1 cells were treated with δ-Tocotrienol, 169 genes were up-regulated and 167 down-regulated. ERK1/2 was shown to play a vital role in cell cycle arrest by gene chips. δ-Tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. CNE1 apoptosis was related to dysregulated expression of Bax-2 and Bcl-2. Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of δ-Tocotrienol.

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PI3K, PDK, δ Tocotrienol, δTocotrienol, Δ-Tocotrienol, δ-Tocotrienol, VEGFR, Delta-Tocotrienol, Bcl-2, Akt, ERK, Inhibitor, p53, inhibit

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Key Properties

No computed properties available.

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δ-Tocotrienol (orb1297642)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 80.00
5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 150.00
10 mg
$ 200.00
25 mg
$ 360.00
50 mg
$ 510.00
100 mg
$ 740.00
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