TPM003

TPM003 (TG062) is a tri-agonist for GLP-1R, GIPR, and GCGR, with EC50 values of 33.9, 12.5, and 92.9 pM, respectively. It suppresses appetite, regulates blood glucose, enhances insulin sensitivity, reduces gastrointestinal intolerance, promotes liver lipid mobilization, and increases energy expenditure. TPM003 induces weight loss, improves metabolic parameters, reverses hepatic steatosis, and optimizes liver function markers. It is applicable in studies of obesity and non-alcoholic steatohepatitis.