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TRAP-14 amide

SKU: orb3142537

Description

TRAP-14 amide is a protease-activated receptor (PAR) activating peptide and acts as a PAR agonist, with an EC50 of 24 μM. It induces significant platelet aggregation via ADP and MMP-2 dependent pathways and is insensitive to Aspirin. Additionally, TRAP-14 amide effectively increases the surface expression of glycoprotein (GP) Ib and GPIIb/IIIa, as well as the release of ADP.

Images & Validation

Key Properties

TargetProtease-activated Receptor,MMP,Integrin
CAS Number141923-36-6
MW1738.94
FormulaC81H119N21O22
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CO)N)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)=O)CC(N)=O)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(=O)N4[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N)=O)=O)CCC4)CCC(O)=O)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CCC2

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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TRAP-14 amide (orb3142537)

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