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TREM2 agonist-1

SKU: orb1687542

Description

TREM2 agonist-1 (I-246) is a small molecule activator of the TREM2 receptor with reported EC50 values ranging from 3.0 to 100 µM. This compound is utilized in research to investigate TREM2's role in microglial function and neurodegenerative diseases, such as Alzheimer's, in both cellular and animal models. Due to stability concerns in its powder form, alternative salt formulations are recommended for experimental use.

Research Area

Neuroscience; Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2738486-70-7
MW437.9
FormulaC23H21ClFN5O
SMILESFC1=C(C=2C3=C(C=C(N2)[C@@H]4C[C@H](OCC4)C5=CN(C)N=C5)N=C(C)C=N3)C=CC(Cl)=C1
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information