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Treosulfan

SKU: orb1307650

Description

Treosulfan (NSC 39069) is a bifunctional alkylating agent with clinical application in advanced ovarian cancer. It is utilized in research settings for in vitro cytotoxicity studies and in vivo models to investigate its antineoplastic mechanisms and potential combination therapies.

Research Area

Molecular Biology

Images & Validation

Key Properties

CAS Number299-75-2
MW278.3
Purity99.75%
FormulaC6H14O8S2
SMILESCS(=O)(=O)OC[C@H](O)[C@@H](O)COS(C)(=O)=O
TargetDNA Alkylator/Crosslinker,DNA Alkylation
SolubilityH2O:50 mg/mL (179.66 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.37 mM);DMSO:100 mg/mL (359.32 mM)

Bioactivity

In Vivo
METHODS: NOD/SCID mice were injected with ES sarcoma cell line TC71 or CHP-100 in the left gastrocnemius muscle. When tumors were palpable, mice were injected with Treosulfan (NSC 39069) (3,000 mg/kg, i.p), busulfan (60 mg/kg, i.p), or vehicle (PBS/20% DMSO, i.p). RESULTS Treosulfan significantly inhibited tumor growth in both cell lines, whereas busulfan only caused an initial inhibition of tumor growth in the cell line TC71 and caused tumor growth in mice injected with the cell line CHP-100 on day 13 Moderately suppressed.
In Vitro
METHODS: ES cell lines A4573, CHP-100, JR (NCI-EWS 94), RD-ES, SK-N-MC, TC32, and TC71 were treated with Treosulfan (NSC 39069)(1, 10, 100, 1000 μM), and cell viability was measured by MTT assay. RESULTS The IC50 values ​​of A4573, CHP-100, JR (NCI-EWS 94), RD-ES, SK-N-MC, TC32, and TC71 were (35, 70, 100, 250, 75, 5, 50, 10 μM).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Treosulfan, Treosulphan, NSC 39069, NSC39069, NSC-39069, inhibit, Inhibitor, Crosslinker, DNA Alkylator/Crosslinker, DNA Alkylator, DNA Alkylation, DNAAlkylator, DNAAlkylation

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    299-75-2

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    1 g, 500 mg, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 25 mg
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Key Properties

No computed properties available.

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Treosulfan (orb1307650)

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% DMSO +
%+
% Tween 80 +
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Available Sizes

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1 ml x 10 mM (in DMSO)
$ 80.00
5 mg
$ 80.00
10 mg
$ 100.00
25 mg
$ 150.00
50 mg
$ 240.00
100 mg
$ 390.00
200 mg
$ 520.00
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