Trioxacarcin B

Trioxacarcin B (TXN-B) is a potent cytotoxic agent and DNA-targeting inhibitor. It disrupts DNA function and induces apoptosis in cancer cells. Trioxacarcin B effectively inhibits the growth of various Gram-positive and Gram-negative bacteria, as well as malignant plasmodium. It also prevents the formation of tumor stem cell colonies and significantly reduces tumor size and prolongs survival in preclinical in vivo models. Its activity is highly dependent on its intact spiroepoxide structure, which becomes ineffective upon hydrolysis. Trioxacarcin B shows no activity against fungi, microalgae, or small RNA viruses. It is applicable in research on bacterial infections, malaria, and various cancers, including colon cancer and melanoma.