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Tropisetron

SKU: orb1305915

Description

Tropisetron (ICS 205-930) is a dual-acting small molecule, functioning as a potent α7-nicotinic acetylcholine receptor agonist and a 5-HT3 receptor antagonist with respective Ki values of 6.9 nM and 5.3 nM. It is widely used in neuroscience research to investigate cholinergic and serotonergic systems in models of cognition, inflammation, and nausea, both in vitro and in vivo.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number89565-68-4
MW284.35
Purity99.95% (May vary between batches)
FormulaC17H20N2O2
SMILESCN1[C@H]2CC[C@H]1CC(C2)OC(=O)c1c[nH]c2ccccc12
TargetDNA/RNA Synthesis,AChR,5-HT Receptor,p38 MAPK,JAK,NF-κB
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.03 mM);DMSO:65 mg/mL (228.59 mM);H2O:50 mg/mL (175.84 mM)

Bioactivity

Target IC50
α7 nAChR:6.9 nM(Ki)|5-HT3 receptor:5.3 nM(Ki)|5-HT3 receptor:70.1 ± 0.9 nM
In Vivo
Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Serotonin Receptor, α7 nAChR, Tropisetronum, Tropisteron, Tropisetron, Inhibitor, ICS 205-930, inhibit, nAChR, Nicotinic acetylcholine receptors, 5HTReceptor, 5-hydroxytryptamine Receptor, 5HT Receptor, 5-HT Receptor, 5-HT3

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Tropisetron (orb1305915)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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10 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
25 mg
$ 120.00
50 mg
$ 170.00
100 mg
$ 240.00
500 mg
$ 560.00
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