Recombinant TYRP1 Antibody / Tyrosinase Related Protein 1 / TRP1

SKU: orb2642117

Description

Tyrosinase-Related Protein-1 / TYRP1 / TRP1 is involved in melanin synthesis. It is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. It is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Images & Validation

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Tested Applications	IHC-P
Dilution Range	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Reactivity	Human
Application Notes	The optimal dilution of the recombinant TYRP1 antibody for each application should be determined by the researcher.

Key Properties

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Antibody Type	Primary Antibody
Host	Rabbit
Clonality	Recombinant
Isotype	Rabbit IgG, kappa
Clone No.	TYRP1/1564R
Immunogen	Human recombinant protein used as the immunogen for this recombinant TYRP1 antibody.
Purification	Protein A affinity chromatography
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Recombinant TYRP1 Antibody / Tyrosinase Related Protein 1 / TRP1

IHC testing of FFPE human melanoma with recombinant TYRP1 antibody, HRP secondary and AEC chromogen. HIER: steam sections in 10 mM Tris with 1 mM EDTA, pH9.0, for 10-20 min.

SDS-PAGE analysis of purified, BSA-free recombinant TYRP1 antibody (clone TYRP1/1564R) as confirmation of integrity and purity.

Quick Database Links

UniProt

P17643

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No UniProt data available

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Protocol Information

IHC-P

Immunohistochemistry Paraffin

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