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Tyk2-IN-5

SKU: orb1708306

Description

Tyk2-IN-5 is a potent, orally bioavailable small molecule inhibitor selectively targeting the Tyk2 JH2 pseudokinase domain with a Ki of 0.086 nM. It demonstrates functional activity in cellular assays, inhibiting IFNα signaling with an IC50 of 25 nM, making it a valuable chemical probe for studying JAK-STAT pathways in autoimmune and inflammatory disease research.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1797432-62-2
MW434.43
FormulaC21H19FN8O2
SMILESCNc1cc(Nc2cccn(-c3ccccn3)c2=O)nn2c(cnc12)C(=O)N[C@@H]1C[C@@H]1F
TargetOthers,JAK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Tyk2-IN-5 (orb1708306)

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