Tylosin tartrate

SKU: orb1224086

Description

Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.(In Vitro):Tylosin tartrate exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit .Tylosin tartrate also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmAI, respectively.(In Vivo):Tylosin tartrate (10-500 mg/kg; s.c.) generally suppresses the elevated TNF-α and IL-1β levels and increases the IL-10 levels in the Lipopolysaccharide (LPS) -treated animals.

Images & Validation

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Key Properties

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CAS Number	74610-55-2
MW	1052.16
Purity	>98% (HPLC)
Formula	C₄₆H₇₇NO₁₇·1/2C₄H₆O₆
SMILES	O=CC[C@@H](C[C@H]1C)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@](C)(O)C3)[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O)CC(O[C@H](CC)[C@@H](CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)/C=C(C)/C=C/C1=O)=O.O[C@H]([C@H](C(O)=O)O)C(O)=O
Target	Others
Solubility	Ethanol: 300 mg/mL (281.37 mM); Water: 200 mg/mL (187.58 mM); DMSO: 300 mg/mL (281.37 mM)

Bioactivity

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In Vivo

Tylosin tartrate (10-500 mg/kg; s. c.) generally suppresses the elevated TNF-α and IL-1β levels and increases the IL-10 levels in the Lipopolysaccharide (LPS)-treated animals. Animal model: Balb/C mice (2-3 months old, 20-25 g). Dosage: 10 mg/kg, 100 mg/kg, 500 mg/kg. Administration: Subcutaneous injection. Result: Reduced the elevated TNF-α and IL-1β in LPS (250 μg)-treated mice but increased their IL-10 levels.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Tylosin tartrate

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