Tylosin tartrate

SKU: orb1310224

Description

Tylosin tartrate is a macrolide antibiotic used in research to study mycoplasma infections in poultry. It is applied in both in vivo and in vitro experiments to investigate its antibacterial mechanisms and efficacy against avian mycoplasmosis.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	74610-55-2
MW	1066.19
Purity	99.16% (May vary between batches)
Formula	C₄₆H₇₇NO₁₇·C₄H₆O₆
SMILES	OC(C(O)C(O)=O)C(O)=O.[H][C@@]1(C[C@@](C)(O)[C@@H](O)[C@H](C)O1)O[C@@H]1[C@@H](C)O[C@@]([H])(O[C@H]2[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@H](CO[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]3OC)[C@@H](CC)OC(=O)C[C@@H](O)[C@@H]2C)[C@H](O)[C@H]1N(C)C
Target	Antibacterial,Antibiotic
Solubility	DMSO:276 mg/mL (258.87 mM);H2O:183 mg/mL (171.64 mM);Ethanol:179 mg/mL (167.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.69 mM)

Bioactivity

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In Vivo

Compared to the control group, Tylosin tartrate (25 mg/L) significantly inhibited methane production, indicating that the concentrations commonly found in swine lagoons negatively affect anaerobic metabolism. In anaerobic incubated sludge, the 90% clearance times for Tylosin, its derivatives Tilmicosin and Relomycin ranged from 30 to 130 hours; this reduced to 12 to 26 hours post aeration. The degradation of Tylosin followed a biphasic pattern with a rapid initial loss followed by a slower elimination phase. Under storage conditions in Milli-Q water (pH 5.7–6.7) at 22°C, Tylosin tartrate remained stable for at least one month.

In Vitro

After intravenous administration of 10 mg/kg Tylosin tartrate, dehydrated camels exhibit significantly higher serum drug concentrations, reduced volume of distribution, and lower clearance rates, with a marked decrease in overall drug elimination speed when compared to normal camels. Furthermore, dehydrated camels receiving a 20 mg/kg dose of Tylosin tartrate via intramuscular injection show reduced average absorption time and lower drug concentrations in the serum. Treatment of neonatal piglets with oral Tylosin tartrate (50 mg/kg, twice daily) for 10 consecutive days, starting 14 days post-intranasal infection, significantly mitigates the severity and incidence of gross pulmonary lesions. Tylosin enhances splenocyte proliferation, yielding higher levels of proliferation in the conditioned medium than in chicken whole spleen cell cultures. Additionally, Tylosin increases the anti-tumor activity of chicken splenic cells.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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poultry, respiratory, rhinitis, veterinary, Tylosin, Tylosin tartrate, Tylosin Tartrate, dysentery, diseases, Bacterial, Antibiotic, atrophic, infections, mycoplasma, inhibit, mastitis, Inhibitor

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Compound Identifiers

PubChem CID

9941488 ↗

Key Properties

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No computed properties available.

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