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UNC2881

SKU: orb1305245

Description

UNC2881 is a potent and selective small molecule inhibitor of Mer tyrosine kinase (MERTK), exhibiting an IC50 of 4.3 nM with 83-fold and 58-fold selectivity over Axl and Tyro3, respectively. This inhibitor is a valuable research tool for studying MERTK signaling in oncology and immunology, applicable in both in vitro cellular assays and in vivo model systems.

Research Area

Infectious Disease & Virology, Signal Transduction

Images & Validation

Key Properties

CAS Number1493764-08-1
MW463.58
Purity99.72%
FormulaC25H33N7O2
SMILESCCCCNc1ncc(C(=O)NCc2ccc(cc2)-n2ccnc2)c(NC2CCC(O)CC2)n1
TargetInfluenza Virus,TAM Receptor
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.12 mM);DMSO:85 mg/mL (183.36 mM);Ethanol:5 mg/mL (10.79 mM)

Bioactivity

Target IC50
Mer:4.3 nM
In Vivo
UNC2881 inhibits the activity of Mer kinase in 697 B-ALL cells (IC50: 22 nM) and suppresses collagen-stimulated platelet aggregation.
In Vitro
In mice, UNC2881 exhibits a high total clearance rate (94.5 ml/kg/min), with an oral bioavailability of 14%.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Axl, AXL, Mer, Inhibitor, inhibit, pathologic thrombosis, orally active, platelet aggregation, TAM Receptor, TAMReceptor, phosphorylation, Tyro3, UNC2881, UNC-2881, UNC 2881

Similar Products

  • UNC2881 [orb1223282]

    >98% (HPLC)

    1493764-08-1

    463.58

    C25H33N7O2

    1 g, 500 mg, 200 mg, 5 mg, 50 mg, 2 mg, 100 mg, 10 mg, 25 mg
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Key Properties

No computed properties available.

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Protocol Information

UNC2881 (orb1305245)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 110.00
25 mg
$ 170.00
50 mg
$ 270.00
100 mg
$ 370.00
200 mg
$ 520.00
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