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Urolithin A

SKU: orb1300010

Description

Urolithin A

Research Area

Cell Biology, Immunology & Inflammation, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1143-70-0
MW228.2
Purity>98%
FormulaC13H8O4
SMILESOc1ccc2c(c1)oc(=O)c1cc(O)ccc21
TargetInflammasome
SolubilitySoluble in DMSO up to 50 mg/ml

Bioactivity

Target IC50
St-T1b cells:39.88 µM|T24 cells:43.9 μM|Caco-2 cells:49 μM|12Z endometriotic cells:40.46 µM|SW620 cells:53.561 μM|CK2:0.39 𝜇M
In Vivo
METHODS: To investigate the effects on Alzheimer's disease (AD), Urolithin A (300 mg/kg, 0.5% carboxymethylcellulose) was administered orally once daily for 14 days to APP/PS1 mouse models. RESULTS: Urolithin A ameliorated cognitive deficits, prevented neuronal apoptosis, and enhanced neurogenesis in APP/PS1 mice.Urolithin A attenuated Aβ deposition and periplaque microglia and astrocyte hyperplasia in the cortex and hippocampus. Urolithin A affects key cell signaling pathways, particularly by enhancing brain AMPK activation, decreasing activation of P65NF-κB and P38MAPK, and inhibiting degradation of Bace1 and APP.
In Vitro
METHODS: Human colorectal cancer cells SW620 were treated with Urolithin A (0-30 µM) for 24 h. Cell viability was measured by MTT assay. RESULTS: A dose-dependent decrease in proliferation was observed in Urolithin A-treated cells. METHODS: Human colorectal cancer cells HT29, SW480 and SW620 were treated with Urolithin A (20-100 µM) for 48 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: Treatment of CRC cells with different concentrations of Urolithin A resulted in a significant increase in Cyclin B1 and CDK6, suggesting a strong cell cycle accumulation in G2/M phase.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Urolithin A, Reactive Oxygen Species, Endogenous Metabolite, inhibit, Inhibitor, apoptosis, Apoptosis, autophagy, Autophagy, DNA/RNA Synthesis, DNA synthesis, Drug Metabolite

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Key Properties

No computed properties available.

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Urolithin A (orb1300010)

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50 mg
$ 170.00
1 g
$ 350.00
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