Ursodeoxycholic acid

SKU: orb1226618

Description

Ursodiol reduces cholesterol absorption and is used to dissolve gallstones.(In Vitro):Ursodeoxycholic acid (10 μM; 24 h) reduces ACE2 and SHP levels in primary airway and intestinal organoids, and reduces SARS-CoV-2 infection in multiple cell types via FXR-mediated ACE2 regulation.\n(In Vivo):Ursodeoxycholic acid (50, 150, and 450 mg/kg; p.o.; daily for 21 days) results in weight loss in C57BL/6J wildtype mice.Ursodeoxycholic acid (1% w/w or 416 mg/kg; oral; 7 days) reduces ACE2 expression in mice and hamsters.Ursodeoxycholic acid (416 mg/kg; oral; 7 days) reduces SARS-CoV-2 infection in hamsters.

Images & Validation

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Key Properties

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CAS Number	128-13-2
MW	392.57
Purity	>98% (HPLC)
Formula	C₂₄H₄₀O₄
SMILES	C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C
Target	Potassium Channel
Solubility	Ethanol: 79 mg/mL (201.23 mM); DMSO: 79 mg/mL (201.23 mM)

Bioactivity

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In Vivo

Animal model: 5 week old C57BL/6J WT mice (male and female). Dosage: 50, 150, and 450 mg/kg dissolved in corn oil. Administration: Oral gavage; daily for 21 days. Result: Mice in the 50 and 450 mg/kg groups sustained significant weight loss within a week. At 50 mg/kg, this weight loss persisted over the course of the experiment. At 450 mg/kg, initially weight loss was noted during the first and third week of ursodiol administration. At 150 mg/kg, it did not have significantly different weights compared to the untreated mice. Animal model: FVB/N mice and Syrian Golden Hamsters. Dosage: 1% w/w for mice, 416 mg/kg for hamsters. Administration: In chow or oral gavage, 7 days. Result: Reduced ACE2 expression. Animal model: Syrian Golden Hamsters, SARS-CoV-2 infection model. Dosage: 416 mg/kg. Administration: Oral gavage, 7 days. Result: Prevented transmission of SARS-CoV-2 in n = 6 out of 9 sentinel animals (33% infected vs. 67% uninfected).

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Potassium Channel

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