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UTL-5g

SKU: orb1217769

Description

UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity. It lowers elevated levels of AST, ALT, creatinine, BUN, and TNF-α, increases the reduced platelet count in mice, and acts as a novel chemo- and radioprotective agent.

Images & Validation

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UTL-5g

Key Properties

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CAS Number646530-37-2
MW271.1
Purity>98% (HPLC)
FormulaC11H8Cl2N2O2
SMILESO=C(C1=NOC(C)=C1)NC2=CC=C(Cl)C=C2Cl
TargetTNF
SolubilityDMSO:10 mM

Bioactivity

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In Vivo
UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation. UTL-5g (60 mg/kg; p.o. ; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times. Animal model: C57BL/6, male mice (8-10 weeks). Dosage: 15, 30, and 60 mg/kg. Administration: i.p.; before irradiation, daily x 5. Result: Blood levels of TGF-β were lowered. Animal model: BDF1 female mice. Dosage: p.o. ; daily for 4 days. Administration: 60 mg/kg (30 min before i.p. injection of Cisplatin at 10, 15, and 20 mg/kg respectively on Day 0). Result: Increased the survival rate and delayed the time to death for mice treated with 150% of the maximum tolerated dose (MTD) of Cisplatin (15 mg/kg). At 200% of the MTD of Cisplatin (20 mg/kg), treatment of UTL-5g increased the survival rate and delayed the time to death.
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In Vitro
RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5 g at 1, 10 or 50 μM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5 g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5 g.
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Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl- | GBL-5g

Similar Products

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  • UTL-5g

    UTL-5g [orb1298588]

    99.83%

    646530-37-2

    271.1

    C11H8Cl2N2O2

    10 mg, 25 mg, 100 mg, 1 ml x 10 mM (in DMSO), 5 mg, 50 mg, 2 mg
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Gene Symbol
TNF

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UTL-5g (orb1217769)

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5 mg
$ 260.00
10 mg
$ 390.00
25 mg
$ 750.00
50 mg
$ 1,040.00
100 mg
$ 1,470.00
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