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Val-Cit-PAB-MMAE

SKU: orb1307265

Description

Val-Cit-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the protease-cleavable Val-Cit-PAB linker and the cytotoxic payload monomethyl auristatin E (MMAE). MMAE potently inhibits tubulin polymerization, disrupting mitosis. This conjugate is widely used in ADC research for targeted cancer therapy, enabling the evaluation of drug delivery and efficacy in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number644981-35-1
MW1123.43
Purity99.66% (May vary between batches)
FormulaC58H94N10O12
SMILESCC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](N)C(C)C)cc1)C(C)C
TargetDrug-Linker Conjugates for ADC,PROTAC Linker
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.45 mM);DMSO:49 mg/mL (43.62 mM)

Storage & Handling

Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Auristatin, DrugLinkerConjugatesforADC, Drug-Linker Conjugates for ADC, DrugLinker Conjugates for ADC, inhibit, Inhibitor, Val Cit PAB MMAE, ValCitPABMMAE, Val-Cit-PAB-MMAE

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Key Properties

No computed properties available.

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Protocol Information

Val-Cit-PAB-MMAE (orb1307265)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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5 mg
$ 90.00
10 mg
$ 110.00