GBR-12909 2HCl

SKU: orb1300023

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Description

Vanoxerine dihydrochloride, also known as GBR-12909 dihydrochloride, is a potent and selective dopamine reuptake inhibitor with an IC50 in the low nanomolar range. This compound is widely used in neuroscience research to study dopaminergic systems, including in vitro binding assays and in vivo models of addiction and Parkinson's disease.

Research Area

Cancer Biology, Neuroscience

Images & Validation

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Key Properties

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CAS Number	67469-78-7
MW	523.5
Purity	>98%
Formula	C₂₈H₃₂F₂N₂O ∙ 2HCl
SMILES	Cl.Cl.Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1
Target	Monoamine transporter
Solubility	Soluble in DMSO (up to 30 mg/ml with warming) or in Water (up to 10 mg/ml with warming).

Bioactivity

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Target IC50

Dopamine uptake:1-51 nM

In Vivo

In 9 SP dogs, 11 episodes each of sustained (>10 minutes) AF and AFL were induced. Electrophysiological studies were performed before and after infusion of vanoxerine, which effectively terminated AF and AFL in 19 of 22 episodes. Simultaneous multisite mapping during 3 AF and 3 AFL episodes demonstrated that termination of each arrhythmia occurred with termination of the driver (a reentrant circuit) following an increase in tachycardia CL. Except for conduction in an area of slow conduction in the driver's reentrant circuit, vanoxerine did not significantly affect intraatrial or atrioventricular conduction time, QRS duration, or QT/QTc intervals. Ventricular refractoriness prolonged minimally during ventricular pacing at 400 and 333 ms (176 +/- 16 ms to 182 +/- 16 ms; 173 +/- 11 ms to 178 +/- 18 ms, respectively). Vanoxerine minimally increased (mean 0.7 mA) atrial stimulus threshold for capture.Vanoxerine dihydrochloridealso blocks ligand binding to sigma receptors in rat brain (IC50 = 48 nM).

Storage & Handling

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Storage	RT
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Vanoxerine dihydrochloride

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Compound Identifiers

PubChem CID

104920 ↗

Key Properties

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No computed properties available.

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GBR-12909 2HCl (orb1300023)

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GBR-12909 2HCl

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

GBR-12909 2HCl (orb1300023)

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