Vardenafil hydrochloride

SKU: orb1685387

Description

Vardenafil hydrochloride is a selective PDE5 inhibitor used in research for erectile dysfunction, particularly in diabetic models. It is applied in both in vitro enzymatic assays and in vivo studies to investigate vascular and smooth muscle function.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	224785-91-5
MW	525.06
Purity	99.94%
Formula	C₂₃H₃₃ClN₆O₄S
SMILES	Cl.CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1
Target	Endogenous Metabolite,PDE
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.81 mM);DMSO:50 mg/mL (95.23 mM);H2O:100 mg/mL (190.45 mM)

Bioactivity

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Target IC50

PDE3:>1000 nM|PDE6:11 nM (IC50)|PDE4:>1000 nM|PDE1:180 nM (IC50)|PDE5:0.7 nM (IC50)

In Vivo

After 12 weeks of treatment, a dose-dependent (P = 0.02) improvement in erections was noted for the GAQ, with 57 and 72% of men taking 10 mg or 20 mg vardenafil, respectively, reporting improved erections, in contrast to 13% after taking placebo (P < 0.0001). For the erectile function domain, dose-dependent (P = 0.03) final scores for the 10- and 20-mg dose were 17.1 and 19.0 compared with 12.6 for placebo (P < 0.0001). Both vardenafil doses significantly enhanced the rates of successful penetration (P < 0.0001) and successful intercourse (P < 0.0001) compared with placebo. Vardenafil treatment was effective in increasing intercourse success rates at all levels of baseline ED severity, at each level of plasma HbA(1c), and for type 1 and 2 diabetes. Treatment-emergent adverse events were primarily mild to moderate headache (

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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erectile, erectile dysfunction, Endogenous Metabolite, hepatitis, Inhibitor, inhibit, muscle, Impotence, diabetes, dysfunction, cGMP, smooth, stimulation, Pharmacokinetics, Phosphodiesterase (PDE), phosphodiesterase, selective, PDE5, PDE-5 inhibitors, Vardenafil, Vardenafil Hydrochloride, Vardenafil hydrochloride, Zucker diabetic fatty (ZDF) rats

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Compound Identifiers

PubChem CID

135438569 ↗

Key Properties

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No computed properties available.

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